Summary
Overview
Work History
Education
Skills
Certification
Publications And Peer Reviewed Works
Countries Worked Travelled
Timeline
Generic

Zandile Carol Mthembu

Senior Project Manager And Public Health Specialist
Johannesburg

Summary

Visionary and accomplished Global Health Executive with over 19 years of experience designing, managing, and optimizing complex, donor-funded public health programs across South Africa. Offers a robust record of leadership in HIV/AIDS prevention and treatment, strategic program development, contract and award management, and public health policy. Expert in guiding multidisciplinary teams and technical specialists, including oversight of AORs and CORs throughout the contract lifecycle. Adept in stakeholder engagement and policy advocacy, driving sustainable impact through cross-sectoral partnerships with governments, donors, research institutions, and civil society. Brings deep experience working in complex, multi-stakeholder environments, confidently representing the United States Government (USG) in national and international forums, technical working groups, and high-level negotiations. Known for innovation, data-driven decision-making, and a steadfast commitment to improving health outcomes for underserved populations.

Overview

2026
2026
years of professional experience
2026
2026
years of post-secondary education
4
4
Certifications

Work History

Senior Biomedical Team Lead: Strategic Prevention

USAID South Africa
09.2023 - Current

orfLed biomedical prevention portfolio ($50M+), including PrEP, PEP, GBV, STI, KP and MHPSS programming.
• Supervise and mentor three Agreement Officer’s Representatives (AORs), all senior technical leads overseeing major HIV prevention portfolios.
• Oversaw the full contract lifecycle, including both pre- and post-award responsibilities : technical input on service needs, development of statements of work (SOWs), market research, proposal evaluation, and solicitation design.
• Provided technical leadership in contract formation, administration, and compliance; reviewed and approved deliverables, ensured quality assurance, advised on changes and modifications, and ensured compliance with performance, health and safety, labor standards, and financial accountability.
• Directed technical activities and coordinated across CORs, monitored reporting systems, and supported contractor HR alignment with scope of work.
• Served as Co-Chair of the HIV Prevention Workstream, collaborating with SANAC, WHO, UNAIDS, NDoH, CEC, the Global Fund, and leading research institutions to align strategies and ensure evidence-based, sustainable implementation.
• Led the introduction of long-acting PrEP prevention technologies (e.g., CAB-LA), working closely with supply chain partners to plan, budget, and integrate into sustainable programming.
• Refocused HIV prevention strategy to align with life-saving programming, integrating community prevention sites as access points for comprehensive and essential care.
• Co-chaired the PEPFAR Prevention Workstream; led planning for Country Operational Plans (COPs).
• Directed stakeholder engagement, interagency coordination, and high-level performance reporting.
.Led biomedical prevention portfolio ($50M+), including PrEP, PEP, GBV, STI, KP and MHPSS programming.

  • Co-chaired PEPFAR Prevention Workstream and led strategic planning aligned with national health priorities.
  • Oversaw development of new awards and program extensions; served as AOR and Activity Manager.
  • Directed performance monitoring, stakeholder engagement, and interagency coordination.
  • Promoted a positive work environment by fostering teamwork, open communication, and employee recognition initiatives.
  • Established clear performance metrics for the team which helped in tracking progress towards set targets effectively.
  • Collaborated with other department leads to streamline workflows, improve interdepartmental coordination, and achieve business goals collectively.
  • Managed risks and mitigated potential issues through proactive planning, monitoring, and timely decisionmaking.

Program Management Specialist: Clinical Cascade

USAID South Africa
08.2021 - 09.2023
  • Designed and led the national TLD Implementation Assessment and tracked the policy’s implementation across government departments, implementing partners, and civil society.
  • Collaborated with the National Department of Health (NDoH) to launch the Multi-Month Dispensing (MMD) and ARV Biweekly Technical Working Group, which I co-chaired alongside NDoH and CDC until the end of my tenure.
  • Oversaw TLD rollout (80% PLHIV transitioned); revised ART guidelines and SOPs.
  • Co-led PEPFAR Treatment TWGs; launched Mental Health and Psychosocial Support (MHPSS) integration.
  • Led outcome evaluations and optimized treatment delivery models.
  • Monitored specific programs' adherence to established schedules and operating budgets.
  • Delivered high-quality results consistently by adhering to established project management methodologies and best practices.
  • Streamlined program management processes by implementing efficient project tracking and reporting tools.
  • Presented monthly metrics to upper management to improve decision-making.
  • Facilitated communication between stakeholders, ensuring timely resolutions for any potential issues or roadblocks.
  • Tracked KPI and monitored net profitability of assigned agreements.
  • Demonstrated exceptional problem-solving skills by resolving critical issues promptly without compromising on quality or timeline.

Chief Executive Officer

Exodus Foundation Ministries
10.2018 - 07.2021
  • Provided overall strategic leadership and operational management for the organization, ensuring alignment with its mission and goals.
  • Developed and implemented long- and short-term organizational strategies, including the Theory of Change, to enhance program impact.
  • Oversaw technical programming across HIV prevention (including DREAMS), treatment, retention, youth empowerment, and community development initiatives.
  • Supervised senior leadership and cross-departmental teams, promoting performance-driven culture and inclusive team-building practices.
  • Led high-level stakeholder engagement with government departments, donors, and partner organizations, maintaining productive partnerships and expanding funding opportunities.
  • Authored successful, award-winning funding proposals and concept notes to major donors and funders.
  • Managed risk mitigation, governance compliance, and institutional sustainability through sound policy frameworks.
  • Represented the organization in public forums, national panels, and donor negotiations.
  • Increased company revenue by implementing innovative business strategies and expanding product offerings.
  • Managed high-performing teams to successfully execute corporate objectives and drive organizational success.
  • Addressed employee and managerial concerns and implemented corrective actions to promote compliance.
  • Engaged positively with staff and leadership colleagues, soliciting and encouraging feedback and collaborative spirit.
  • Negotiated favorable contracts with suppliers and vendors, ensuring cost-effective procurement processes.
  • Implemented strong financial controls, ensuring accurate reporting and solid decision-making capabilities.
  • Managed partnerships and strategic business relationships by negotiating contract terms and handling conflicts.
  • Drove continuous improvement by fostering a culture of collaboration, accountability, and open communication across all levels of the organization.

Senior QI Advisor/KZN POC

CDC South Africa / U.S. Department of State
11.2017 - 08.2018
  • Provided technical leadership for QI across HIV programs; supported HTS TWG.
  • Prepared interagency reports, cables, and briefs.
  • Developed long-lasting relationships with clients to ensure consistent retention and loyalty.
  • Maintained up-to-date knowledge on industry trends and regulations, ensuring accurate advice was provided to clients at all times.
  • Managed risk effectively by closely monitoring client portfolios and making timely adjustments.
  • Participated in ongoing professional development opportunities to stay current with industry trends and best practices.
  • Developed strong relationships with clients through regular communication and excellent customer service.
  • Facilitated workshops on financial planning for high-net-worth individuals, improving their understanding of wealth management.
  • Collaborated with cross-functional teams to launch series of successful financial education seminars.
  • Led team in development of digital advisory platform, enhancing accessibility and engagement for clients.
  • Increased client satisfaction, providing personalized investment advice based on thorough financial analysis.
  • Enhanced advisor skills and knowledge through continuous professional development program, elevating service quality.
  • Used standardized assessments to evaluate abilities, interests and characteristics of different students.

Senior Program Manager (Consultant)

Maternal, Adolescent & Child Health Systems (MatCH
04.2016 - 03.2017
  • Led establishment of DREAMS programming; coordinated AGYW stakeholder engagement and implementation.
  • Managed cross-functional teams to deliver high-quality products within scope and budget constraints.
  • Championed continuous improvement initiatives within the organization, driving efficiency gains across all projects.
  • Facilitated stakeholder communication, leading to improved alignment between business objectives and program goals.
  • Led process improvement initiatives by conducting thorough analyses of existing workflows, identifying bottlenecks and redundancies that hindered progress toward established targets.
  • Established clear performance metrics for tracking program success, enabling informed decision-making processes throughout each project''s duration.
  • Developed comprehensive project plans, resulting in successful on-time delivery of multiple programs.
  • Delivered engaging presentations to stakeholders at all levels, effectively communicating complex information in a clear and concise manner.
  • Ensured compliance with industry regulations and organizational policies throughout the program lifecycle, mitigating potential risks or liabilities for the company.

HIV Testing Services Lead

CDC South Africa
09.2013 - 03.2016
  • Convened national HTS policy revision; led development of registers and combination prevention policy.
  • Established KZN provincial office and implemented quality improvement (QI) initiatives.
  • Worked well in a team setting, providing support and guidance.

Senior PEPFAR Programs Assessor

Social & Scientific Systems, Inc.
01.2009 - 01.2014
  • Conducted comprehensive assessments for USAID/CDC-funded programs; designed evaluation tools and dashboards.
  • Managed workload effectively by prioritizing tasks according to deadlines while maintaining attention to detail in all aspects of the assessment process.
  • Produced reports with detailed valuations.
  • Achieved high levels of compliance through regular audits of exemption applications and adherence to established guidelines for qualification determination.
  • Completed appraisals on pre-set number of properties to meet weekly production goals.
  • Continuously improved assessment procedures through regular review of internal processes, incorporation of feedback from stakeholders, and adaptation to changing industry standards.
  • Documented condition and special features to provide accurate estimations.
  • Collaborated with team members to complete large-scale reassessments on time, ensuring equitable distribution of tax burdens among property owners.

Associate Academic Director

School for Internal Training
  • Collaborated with faculty members to design interdisciplinary courses that broadened student perspectives and enriched their educational experience.
  • Ensured compliance with accreditation standards by maintaining rigorous academic policies and procedures.
  • Fostered a culture of continuous improvement by regularly soliciting feedback from students, faculty members, and other stakeholders.
  • Provided professional development opportunities for faculty members, empowering them to excel in their teaching roles.
  • Improved student retention rates by developing and executing targeted academic support programs.

HIV & TB Provincial Manager

KwaZulu-Natal Department of Health
  • Accomplished multiple tasks within established timeframes.

Programme Manager

Broadreach Healthcare
  • Managed cross-functional teams for successful project completion within deadlines and budgets.
  • Managed multiple strategic projects with numerous sub-projects or workstreams.

Clinical Research Manager

Human Sciences Research Council
  • Negotiated contracts with vendors, securing competitive pricing for critical study supplies and services.
  • Championed continuous improvement initiatives within the department, driving process enhancements that increased overall efficiency.

Education

Ph.D. - Counselling Psychology

University of KwaZulu-Natal
Durban
05.2025

Master of Social Sciences - Sociology & Public Policy

University of KwaZulu-Natal

BSc Honours - Psychology

University of Natal

BSc - Psychology & Sociology

University of Natal

Skills

  • Strategic Leadership & Oversight
  • Organizational Management
  • Technical Expertise
  • Program & Grant Management
  • Research & Analysis

    Professional Writing

    Coaching and mentoring

    Resource allocation

    Stakeholder management

    Project management

    Risk management

    Budget management

    Change management

    Program development

    Teamwork and collaboration

    Quality improvement

    Work Planning and Prioritization

Certification

Project Management Professional (PMP)

Publications And Peer Reviewed Works

  • Oral PrEP Implementation in South Africa: A USAID Case Study, Milimu et al., 2024, Front. Reprod. Health
  • Mental Health of HIV/TB Healthcare Workers During COVID-19, Yang et al., 2023, BMC Health Serv Res 23, 727
  • Outcomes of TLD-based ARV Therapy, Mali et al., 2024, IAS 2024, Germany
  • Risks Among Children of Sex Workers in SA, Thurman et al., 2024, Intl. Workshop on HIV & Pediatrics, Germany
  • Global Health Technical Assistance Project, Gruber von Kerenshazy et al., n.d., USAID SA

Countries Worked Travelled

South Africa, Zimbabwe, Lesotho, Tanzania, USA, UK, Germany, Thailand, Zambia, Botswana

Timeline

Senior Biomedical Team Lead: Strategic Prevention

USAID South Africa
09.2023 - Current

Program Management Specialist: Clinical Cascade

USAID South Africa
08.2021 - 09.2023

Chief Executive Officer

Exodus Foundation Ministries
10.2018 - 07.2021

Senior QI Advisor/KZN POC

CDC South Africa / U.S. Department of State
11.2017 - 08.2018

Senior Program Manager (Consultant)

Maternal, Adolescent & Child Health Systems (MatCH
04.2016 - 03.2017

HIV Testing Services Lead

CDC South Africa
09.2013 - 03.2016

Senior PEPFAR Programs Assessor

Social & Scientific Systems, Inc.
01.2009 - 01.2014

Master of Social Sciences - Sociology & Public Policy

University of KwaZulu-Natal

BSc Honours - Psychology

University of Natal

BSc - Psychology & Sociology

University of Natal

Associate Academic Director

School for Internal Training

HIV & TB Provincial Manager

KwaZulu-Natal Department of Health

Programme Manager

Broadreach Healthcare

Clinical Research Manager

Human Sciences Research Council

Ph.D. - Counselling Psychology

University of KwaZulu-Natal
Zandile Carol MthembuSenior Project Manager And Public Health Specialist