DUDUZILE NDWANDWE
Deputy Director: Specialist Scientist
Cape Town
Summary
Versatile Deputy Director and Seasoned Scientist with over 10 years of medical health research experience. Works well with diverse stakeholders to accomplish objectives, drive productivity and streamline operations. Expertise includes administration, fiscal management and performance improvements. Also includes publication in peer-reviewed journals, mentor students, provide intellectual input at national and international working groups, and a peer reviewer to various academic journals
Overview
11
11
years of professional experience
5
5
Languages
Work History
Deputy Director
Cochrane South Africa, South African Medical Research Council
05.2021 - Current
- Delivered data outcomes to internal and external staff to drive continuous improvement and client engagement.
- Contributed to short- and long-term strategic planning and identified potential new markets, lines of business and funding opportunities.
- Participated in risk assessment analysis for all new lines of business and for continuation of existing lines of business.
- Turned mandates into actionable operational strategies.
- Liaised with legal counsel to address legal issues, contract review and governing instruments.
- Developed thought leadership around specific topics and emerging practice areas in support of budget, financial and operational goals.
- Modernized operations with strategic process improvements.
- Fostered improved collection and use of client and industry data for strategic business decisions and reporting.
- Determined agenda, developed plans and oversaw implementation of programs and updates.
- Collaborated with Africa CDC and WHO agencies to accomplish key objectives.
- Improved coordination and communications across organization to increase operational efficiency.
- Oversaw corporate communications and branding strategies for consistency and quality.
- Trained and developed department leaders and management staff for specific projects and ongoing operational needs.
- Assisted senior leadership in managing all aspects of operations.
- Prioritized tasks and allocated resources appropriately to keep teams focused and productive.
Board Chair
Eh!Woza
01.2020 - Current
- Compiled and analyzed metrics for detailed reporting and informed business planning.
- Contributed to values, goals and strategic vision of organization.
- Negotiated and resolved conflicts between stakeholders.
- Recruited, developed and retained excellent faculty to meet organizational goals.
- Chaired shareholder meetings, disseminating information, and fielded questions.
- Developed innovative approaches to problem-solving, leveraging resources and driving results.
- Composed and transcribed well-written reports, emails and technical documents with minimal supervision.
- Provided recommendations on board of directors on group's effectiveness, actions, and future plans.
- Spearheaded development and implementation of corporate governance strategies, confirming compliance with regulations at all times.
- Led organization in setting goals and strategies.
Specialist Scientist
Cochrane, South African Medical Research Council
10.2017 - Current
- Interpreted clients' needs and introduced services to fit specific requirements.
- Followed all company policies and procedures to deliver quality work.
- Attended training programs to deepen professional skillset and assisted in training fellow store associates on existing and new training programs.
- Assisted with staff training to enforce quality, safety and sanitation guidelines.
- Collaborated with internal departments to align marketing campaigns.
- Maintained current understanding of market conditions, compliance standards and best practices.
- Coordinated and executed marketing campaigns to generate new leads and sales opportunities.
- Built and managed relationships with key clients and partners to drive growth.
- Created and delivered presentations to internal and external stakeholders to showcase work.
- Analyzed marketing data and trends to identify opportunities for improvement.
- Monitored industry trends to adapt strategies accordingly.
- Developed effective improvement plans in alignment with goals and specifications.
- Generated reports detailing findings and recommendations.
- Created and managed project plans, timelines and budgets.
- Provided reporting for forecast analysis and ad-hoc reporting in support of decision-making.
- Collected, arranged, and input information into database system.
- Developed and updated tracking spreadsheets for process monitoring and reporting.
- Frequently inspected production area to verify proper equipment operation.
- Helped meet changing demands by recommending improvements to business systems or procedures.
- Gathered, organized and input information into digital database.
- Conducted regular reviews of operations and identified areas for improvement.
- Educated staff on organizational mission and goals to help employees achieve success.
- Maintained database systems to track and analyze operational data.
Senior Researcher, Project Lead
Wits Reproductive Health & HIV Institute
02.2016 - 07.2017
- For HPTN 082, EMPOWER clinical trials
- Planned, executed, and controlled assigned projects, ensuring work performed complied with contractual requirements.
- Met with manager weekly to provide detailed project report and milestone updates.
- Maintained tactical control of project budgets and timelines to keep teams on task and achieve schedule targets.
- Presented findings and demonstrated concepts at conferences and events.
- Partnered with project team members to identify and quickly address problems.
- Produced quality standards, checklists, report templates, and processes.
- Managed documentation according to company guidelines and compliance requirements.
- Set up and managed team meetings.
- Led team of engineers in providing design and engineering solutions to various clients and market sectors.
- Recruited, hired and supervised resources to staff project team.
- Provided ongoing cost and estimate analysis reporting and managed cost allocation.
- Obtained funding and worked with backers to assess research goals and implement relevant plans.
- Developed and trained junior team members by leveraging industry experience to achieve optimal project strategy.
- Maintained research materials, equipment and facilities in good working order.
- Analyzed financial reporting systems and project schedules to proactively address potential problems.
- Adjusted project plans to account for dynamic targets, staffing changes, and operational specifications.
Postdoctoral Research Fellow
School, Health Sciences, University of KwaZulu-Natal
01.2015 - 01.2016
- Maintained accurate records of research findings and provided statistical analysis of data results.
- Contributed to and actively participated in research conception, design and execution to address defined problems.
- Developed unique research into Naringin protection against HIV-1 protease inhibitors-induced pancreatic β-cell dysfunction and apoptosis.
- Collaborated with science professionals to advance research and gain deeper understanding of topics.
Senior Scientist
South African Medical Research Council
01.2013 - 01.2015
- Documented changes during experiments, noting unexpected issues arising during research activities.
- Conducted experiments in laboratory environment for product development purposes.
- Simultaneously managed several complex projects, meeting all pertinent milestones.
- Prioritized project tasks after discussions with staff department team.
- Performed complex troubleshooting and assisted in leading initiatives to solve challenging scientific problems with assays or instrumentation.
- Trained new employees on areas of technical expertise and compliance issues relevant to lab setting.
- Read literature related to scientific area of expertise to remain current in knowledge.
- Followed strict safety protocols, protecting staff and assets while carrying out technical procedures and research protocols.
- Conducted document review, organization and quality control of data acquisition to draw relevant conclusions and direct research activities.
Teaching Assistant
University of the Witwatersrand
01.2007
- Tutored struggling students individually and in small groups to reinforce learning concepts.
- Partnered with teacher to plan and implement lessons following school's curriculum, goals, and objectives.
- Supported classroom activities, tutoring, and reviewing work.
- Assisted teachers with classroom management and document coordination to maintain positive learning environment.
- Facilitated activities in small groups to reinforce concepts taught by class teacher.
Limpopo, Microbiology Department
01.2006
- Documented changes during experiments, noting unexpected issues arising during research activities.
- Conducted experiments in laboratory environment for product development purposes.
- Simultaneously managed several complex projects, meeting all pertinent milestones.
- Prioritized project tasks after discussions with lab technician department team.
- Followed strict safety protocols, protecting staff and assets while carrying out technical procedures and research protocols.
- Learned new laboratory techniques and applied expertise in carrying out enhanced experiments under supervision of senior lab members.
Education
Master of Science - Vaccinology
University of Lausanne
Switzerland 09.2021 - 09.2021
PhD - Molecular Mycobacteriology
University of the Witwatersrand
MSc - Microbial Genetics
University of the Witwatersrand
Bachelor of Science (Honours) - Microbiology
University of Limpopo
Bachelor of Science - Physiology and Microbiology
University of Limpopo
Matric Senior Certificate - undefined
Sikhulile Secondary School
Master’s - public health
University of Cape Town
Advanced Diploma - Vaccinology
University of Geneva
Geneva 05.2022 - 06.2022
Skills
Program oversight
SAMRC Cochrane SA Operations background
Strategic planning
Change Management
Process improvements
Database development
Strategic leadership
Financial administration
Schedule Coordination
Key relationship management
Staff Management
Budgeting
Business planning
Accomplishments
Peer-reviewed Publications
1st author publications
1. Ndwandwe DE, Runeyi S, Pienaar E, Mathebula L, Hohlfeld A, Wiysonge CS. Practices and trends in clinical trial registration in the Pan African Clinical Trials Registry (PACTR): a descriptive analysis of registration data. BMJ Open. 2022 Jan 25;12(1):e057474. doi: 10.1136/bmjopen-2021-057474. PMID: 35078852.
2. Ndwandwe D, Wiysonge CS. COVID-19 vaccines. Curr Opin Immunol. 2021 Jul 12;71:111-116. doi: 10.1016/j.coi.2021.07.003. Epub ahead of print. PMID: 34330017; PMCID: PMC8272971
3. Ndwandwe D, Mathebula L, Adetokunboh O, Kamadjeu R, Wiysonge CS. Cochrane corner: universal screening for SARS-CoV-2 infection. Pan African Medical Journal 2020 Dec 16;37:(Supp 1):48. [doi: 10.11604/pamj.supp.2020.37.1.26881]
4. Ndwandwe D, Ngcobo NJ, Adamu AA, Nnaji C, Mashunye T, Leufak AM, Cooper S, Uthman OA, Wiysonge CS. Country-Level Assessment of Missed Opportunities for Vaccination in South Africa: Protocol for Multilevel Analysis. JMIR Res Protoc. 2020 Sep 28;9(9):e16672.
doi: 10.2196/16672.
5. Ndwandwe D, Mathebula L, Kamadjeu R, Wiysonge CS. Cochrane corner: rapid point-of-care antigen and molecular-based tests for the diagnosis of COVID-19 infection. Supplement article - Research | Volume 37 (1): 10. 15 Sep 2020 | 10.11604/pamj.supp.2020.37.1.25982
6. Ndwandwe D, Nnaji CA, Mashunye T, Uthman OA, Wiysonge CS. Incomplete vaccination and associated factors among children aged 12–23 months in South Africa: an analysis of the South African demographic and health survey 2016. Human Vaccines & Immunotherapeutics 2020, July 23. Doi:10.1080/21645515.2020.1791509.
https://doi.org/10.1080/21645515.2020.1791509
7. Ndwandwe D, Dube K, Mathebula L, Wiysonge CS. 2019. Description of vaccine clinical trials in Africa: a narrative review. Hum Vaccin Immunother. 2020 Apr 2;16(4):972-980.
doi: 10.1080/21645515.2019.1693720. PMID: 31730397
8. Ndwandwe D, Uthman OA, Adamu A, Sambala E, Yusuf T, Bishwajit G, Yaya S, Wiysonge CS. Decomposing the gap in missed opportunities for vaccination between poor and non-poor in sub-Saharan Africa: A Multicountry Analyses. Hum Vaccin Immunother. 2018;14(10):2358-2364. doi: 10.1080/21645515.2018.1467685. PMID: 29688133
9. Ndwandwe DE, Abbai NS, Wand H, Ramjee G. The Need for Multi-product Technologies for Women Participating in Vaginal Microbicide Trials. AIDS research and human retroviruses. 2014: 30 (S1), A140-A141
10. Ndwandwe D, Nnaji CA, Wiysonge CS. The magnitude and determinants of missed opportunities for childhood vaccination in South Africa. Vaccines 2020, 8(4), 705; https://doi.org/10.3390/vaccines8040705
11. Ndwandwe, D., Runeyi, S., Mathebula, L. et al. Rotavirus vaccine clinical trials: a cross-sectional analysis of clinical trials registries. Trials 23, 945 (2022). https://doi.org/10.1186/s13063-022-06878-6
Senior authorship
12. Nnaji CA, Wiysonge CS, Cooper S, Mayeye A, Luphondo L, Mabuya T, Kalui N, Lesosky M, Ndwandwe D. Contextualising missed opportunities for children's vaccination: A theory-informed qualitative study in primary care settings in Cape Town, South Africa. Hum Vaccin Immunother. 2023 Jan 5:2162771. doi: 10.1080/21645515.2022.2162771. Epub ahead of print. PMID: 36601915.
13. Nnaji CA, Wiysonge CS, Adamu AA, Lesosky M, Mahomed H, Ndwandwe D. Missed Opportunities for Vaccination and Associated Factors among Children Attending Primary Health Care Facilities in Cape Town, South Africa: A Pre-Intervention Multilevel Analysis. Vaccines (Basel). 2022 May 16;10(5):785. doi: 10.3390/vaccines10050785. PMID: 35632542; PMCID: PMC9144782.
14. Mathebula, L., Runeyi, S., Wiysonge, C., Ndwandwe D. Clinical trial registration during COVID-19 and beyond in the African context: what have we learned?. Trials 23, 460 (2022). https://doi.org/10.1186/s13063-022-06412-8
15. Ngandu, N.K., Mmotsa, T.M., Dassaye, R. Thabetha A, Odendaal, Langdown N, Ndwandwe D. Hospital acquired COVID-19 infections amongst patients before the rollout of COVID-19 vaccinations, a scoping review. BMC Infect Dis 22, 140 (2022). https://doi.org/10.1186/s12879-022-07128-5
16. Jaca A, Sishuba M, Jacobson Vann JC, Wiysonge CS, Ndwandwe D. Interventions to improve vaccination uptake among adults. Cochrane Database of Systematic Reviews 2021, Issue 11. Art. No.: CD015057. DOI: 10.1002/14651858.CD015057. Accessed 17 November 2021.
17. Adetokunboh O, Iwu-Jaja CJ, Nnaji CA, Ndwandwe D. Missed opportunities for vaccination in Africa. Curr Opin Immunol. 2021 Aug; 71:55-61. doi: 10.1016/j.coi.2021.05.002. Epub 2021 Jun 1. PMID: 34087523.
18. Nnaji CA, Wiysonge CS, Lesosky M, Mahomed H, Ndwandwe D. COVID-19 and the Gaping Wounds of South Africa’s Suboptimal Immunisation Coverage: An Implementation Research Imperative for Assessing and Addressing Missed Opportunities for Vaccination. Vaccines. 2021; 9(7):691. https://doi.org/10.3390/vaccines9070691
19. Leufak AM, Ndwandwe D. Applying innovative strategies to achieve Universal Health Coverage in the African Region. (Position paper). SEEJPH 2021, posted: 18 May 2021. DOI: 10.11576/seejph-4447
Co-authored publications
20. Mthembu SXH, Mazibuko-Mbeje SE, Moetlediwa MT, Muvhulawa N, Silvestri S, Orlando P, Nkambule BB, Muller CJF, Ndwandwe D, Basson AK, Tiano L, Dludla PV. Sulforaphane: A nutraceutical against diabetes-related complications. Pharmacol Res. 2023 Sep 12;196:106918. doi: 10.1016/j.phrs.2023.106918. Epub ahead of print. PMID: 37703962.
21. Dludla PV, Cirilli I, Marcheggiani F, Silvestri S, Orlando P, Muvhulawa N, Moetlediwa MT, Nkambule BB, Mazibuko-Mbeje SE, Hlengwa N, et al (including Ndwandwe D). Potential Benefits of Coffee Consumption on Improving Biomarkers of Oxidative Stress and Inflammation in Healthy Individuals and Those at Increased Risk of Cardiovascular Disease. Molecules. 2023; 28(18):6440. https://doi.org/10.3390/molecules28186440
22. Dludla PV, Cirilli I, Marcheggiani F, Silvestri S, Orlando P, Muvhulawa N, Moetlediwa MT, Nkambule BB, Mazibuko-Mbeje SE, Hlengwa N, et al (including Ndwandwe D). Bioactive Properties, Bioavailability Profiles, and Clinical Evidence of the Potential Benefits of Black Pepper (Piper nigrum) and Red Pepper (Capsicum annum) against Diverse Metabolic Complications. Molecules. 2023; 28(18):6569. https://doi.org/10.3390/molecules28186569
23. Wiysonge CS, Ndwandwe D and Mathebula L. Measles and whooping cough outbreaks in South Africa: a sign of low vaccination coverage, experts warn. The conversation article published June 15, 2023. URL: https://theconversation.com/measles-and-whooping-cough-outbreaks-in-south-africa-a-sign-of-low-vaccination-coverage-experts-warn-205515
Masuku, S., Mooa, R. S., Peu, M. D., Ndwandwe, D., Moloto, T. B. S., & van der Walt, M. (2023). Exploring the role of healthcare personnel in designing Tuberculosis Infection Prevention and Control measures in healthcare settings: A scoping review.
24. Foster I, Amuasi J, Geelen J, Miyagawa S, Böcking D, Hagen H, Sigfrid L, Norton A; GloPID-R Clinical Trial Networks and Funders Working Group (including Ndwandwe D). How funders can support improved clinical trial practice for outbreaks. Lancet. 2023 Jul 1;402(10395):26. doi: 10.1016/S0140-6736(23)01226-6. PMID: 37393101.
25. Shelly CE, Logan C, Skorochod B, Wiyeh A, Ndwandwe D, Choko A, Valea I, Titanji BK. Creating a best practice template for participant communication plans in global health clinical studies. Trials. 2023 Mar 2;24(1):158. doi: 10.1186/s13063-023-07185-4. PMID: 36864516; PMCID: PMC9983505.
26. Ibrahim SK, Ndwandwe DE, Thomas K, Sigfrid L, Norton A. Sudan virus disease outbreak in Uganda: urgent research gaps. BMJ Glob Health. 2022 Dec;7(12):e010982. doi: 10.1136/bmjgh-2022-010982. PMID: 36585031; PMCID: PMC9809242.
27. Shelly CE, Logan C, Skorochod B, Wiyeh A, Ndwandwe D, Choko A, Valea I, Titanji BK. Creating a Best Practice Template for Participant Communication Plans in Global Health Clinical Studies. Research Square; 2022. DOI: 10.21203/rs.3.rs-2378482/v1.
28. GBD 2019 Diabetes and Air Pollution Collaborators (including Ndwandwe D). Estimates, trends, and drivers of the global burden of type 2 diabetes attributable to PM2·5 air pollution, 1990-2019: an analysis of data from the Global Burden of Disease Study 2019. Lancet Planet Health. 2022 Jul;6(7):e586-e600. doi: 10.1016/S2542-5196(22)00122-X. PMID: 35809588.
29. GBD 2019 Human Resources for Health Collaborators (including Ndwandwe D). Measuring the availability of human resources for health and its relationship to universal health coverage for 204 countries and territories from 1990 to 2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet. 2022 Jun 4;399(10341):2129-2154. doi: 10.1016/S0140-6736(22)00532-3. Epub 2022 May 23. PMID: 35617980; PMCID: PMC9168805.
30. Be ZO and Ndwandwe D. AFRICA IS SEEKING COVID TREATMENTS BUT MAJOR HURDLES BLOCK THE WAY. Nature. 2021 Nov 4;599:25.
31. Mathebula L, Mapahla L, Nurkhametova D, Ziganshina LE, Mazinu M, Jordan E, Ndwandwe DE, Kredo T. Planned, ongoing and completed tuberculosis treatment trials in Brazil, Russia, India, China, and South Africa: a 2019 cross-sectional descriptive analysis. BMJ Open. 2022;12:e057941. doi:10.1136/bmjopen-2021-057941
32. Wiysonge, C. S., Ndwandwe, D., Mathebula, L., Goga, A., & Gray, G. (2022). Randomised trials of COVID-19 vaccines in Africa – charting the path forward. South African Journal of Science, 118(5/6). https://doi.org/10.17159/sajs.2022/13224
33. Mouako AL, Zunza M, Ndwandwe D, Uthman OA, Wiysonge CS. Health research publications by South African authors from 1996 to 2015: a bibliometric analysis. Pan Afr Med J. 2022 May 12;42:31. doi: 10.11604/pamj.2022.42.31.28968. PMID: 35910065; PMCID: PMC9288119.
34. Mavundza EJ, Ndwandwe D, Wiysonge CS. COVID-19 vaccine demand protest might have increased vaccine acceptance and uptake in South Africa. Hum Vaccin Immunother. 2022 Apr 18:1-3. doi: 10.1080/21645515.2022.2064691. Epub ahead of print. PMID: 35435798.
35. Merson L, Ndwandwe D, Malinga T, Paparella G, Oneil K, Karam G, Terry RF. Promotion of data sharing needs more than an emergency: An analysis of trends across clinical trials registered on the International Clinical Trials Registry Platform. Wellcome Open Res 21 Mar 2022, 7:101. doi: https://doi.org/10.12688/wellcomeopenres.17700.1
36. Uthman OA, Ndwandwe D, Uthman MMB, Yaya S, Wiysonge CS. Multilevel Analysis of Individual and Contextual Factors Associated with Polio Non-Vaccination in Africa: Further Analyses to Enhance Policy and Opportunity to Save More Lives. Vaccines 2021; 9(7):683. https://doi.org/10.3390/vaccines9070683
37. Nnaji CA, Ndwandwe D, Lesosky M, Mahomed H, Wiysonge CS. Tackling missed opportunities for vaccination in a new era of immunisation. Lancet. 2021 Jun 2:S0140-6736(21)01226-5. Epub ahead of print. PMID: 34089659; PMCID: PMC8172164. doi: 10.1016/S0140-6736(21)01226-5
38. Wiysonge CS, Ndwandwe D, Ryan J, Jaca A, Batouré O, Anya BM, Cooper S. 2021. Vaccine hesitancy in the era of COVID-19: could lessons from the past help in divining the future? Hum Vaccin Immunother. 2021 Mar 8;1-3. doi: 10.1080/21645515.2021.1893062.
39. Mashunye TR, Ndwandwe DE, Dube KR, Shey M, Shelton M, Wiysonge CS. Fractional dose compared with standard dose inactivated poliovirus vaccine in children: a systematic review and meta-analysis. Lancet Infect Dis. 2021 Apr 30:S1473-3099(20)30693-9. doi: 10.1016/S1473-3099(20)30693-9. Online ahead of print. PMID: 33939958
40. Mathebula L, Ndwandwe DE, Pienaar E, Wiysonge CS. Effects of vaccines in protecting against Ebola virus disease: protocol for a systematic review. BMJ Open. 2019 Jul 3;9(7):e029617. doi: 10.1136/bmjopen-2019-029617.PMID: 31272985
41. Mahasha P, Ndwandwe D, Mavundza E, Shey M, Wiysonge CS. Systematic review protocol on Bacillus Calmette-Guerin (BCG) revaccination and protection against tuberculosis BMJ Open 2019;9:e027033. doi: 10.1136/bmjopen-2018-027033.
42. Mashunye TR, Ndwandwe D, Dube K, Shey M, Wiysonge CS. A protocol for a systematic review and meta-analysis of fractional dose compared to standard dose inactivated polio vaccination in children. BMJ Open. 2019 Mar 9;9(3):e023308. doi: 10.1136/bmjopen-2018-023308. PMID: 30852530
43. Sambala EZ, Ndwandwe DE, Imaan LM, Wiysonge CS. Evaluation of influenza surveillance systems in sub-Saharan Africa: a systematic review protocol. BMJ Open. 2019 Jan 28;9(1): e023335. doi: 10.1136/bmjopen-2018-023335.PMID: 30782704
44. Adetokunboh OO, Ndwandwe D, Awotiwon A, Uthman OA, Wiysonge CS. Vaccination among HIV-infected, HIV-exposed uninfected and HIV-uninfected children: a systematic review and meta-analysis of evidence related to vaccine efficacy and effectiveness. Hum Vaccin Immunother. 2019 May 22:1-12. doi: 10.1080/21645515.2019.1599677. [Epub ahead of print]. PMID: 30945967
45. Nzuza S, Ndwandwe DE, Owira PMO. Naringin protects against HIV-1 protease inhibitors-induced pancreatic β-cell dysfunction and apoptosis. Mol Cell Endocrinol. 2016 Dec 5; 437:1-10. doi: 10.1016/j.mce.2016.07.041. PMID: 27496642
46. Warner DF, Ndwandwe DE, Abrahams GL, Kana BD, Machowski, E, Venclovas, C. and Mizrahi V. 2010. Essential roles for imuA′- and imuB-encoded accessory factors in DnaE2-dependent mutagenesis in Mycobacterium tuberculosis. PNAS. 107 (29): 13093-13098
47. Achoki T, Sartorius B, Watkins D, Glenn SD, Kengne AP, Oni T, Wiysonge CS, Walker A, Adetokunboh OO, Babalola TK, Bolarinwa OA, Claassens MM, Cowden RG, Day CT, Ezekannagha O, Ginindza TG, Iwu CCD, Iwu CJ, Karangwa I, Katoto PD, Kugbey N, Kuupiel D, Mahasha PW, Mashamba-Thompson TP, Mensah GA, Ndwandwe DE, Nnaji CA, Ntsekhe M, Nyirenda TE, Odhiambo JN, Oppong Asante K, Parry CDH, Pillay JD, Schutte AE, Seedat S, Sliwa K, Stein DJ, Tanser FC, Useh U, Zar HJ, Zühlke LJ, Mayosi BM, Hay SI, Murray CJL, Naghavi M. Health trends, inequalities and opportunities in South Africa's provinces, 1990-2019: findings from the Global Burden of Disease 2019 Study. J Epidemiol Community Health. 2022 Jan 19:jech-2021-217480. doi: 10.1136/jech-2021-217480. Epub ahead of print. PMID: 35046100.
48. Bergman H, Henschke N, Hungerford D, Pitan F, Ndwandwe D, Cunliffe N, Soares-Weiser K. Vaccines for preventing rotavirus diarrhoea: vaccines in use. Cochrane Database of Systematic Reviews 2021, Issue 11. Art. No.: CD008521. DOI: 10.1002/14651858.CD008521.pub6. Accessed 17 November 2021.
49. Bhattacharjee NV, Schaeffer LE, Hay SI; Local Burden of Disease Exclusive Breastfeeding Collaborators (including Ndwandwe D). Mapping inequalities in exclusive breastfeeding in low- and middle-income countries, 2000-2018. Nat Hum Behav. 2021 Jun 3. doi: 10.1038/s41562-021-01108-6. Epub ahead of print. PMID: 34083753.
50. Adetokunboh O, Iwu-Jaja CJ, Nnaji CA, and Ndwandwe D. Missed opportunities for vaccination in Africa. Current Opinion in Immunology 2021, 71:55–61. Doi: https://doi.org/10.1016/j.coi.2021.05.002.
51. Hohlfeld ASJ, Mathebula L, Pienaar ED, Abrams A, Lutje V, Ndwandwe D, Kredo T.
Tuberculosis treatment intervention trials in Africa: A cross-sectional bibliographic study and spatial analysis. PLoS One. 2021 Mar 19;16(3):e0248621. doi: 10.1371/journal.pone.0248621. eCollection 2021.PMID: 33739989
52. Malinga T, Wiysonge CS, Ndwandwe D, Okeibunor JC, Talisuna AO. 2021. A scoping review of the impact of long-distance truck drivers on the spread of COVID-19 infection. PAMJ. Volume 38, Article 27, 12 Jan 2021 | 10.11604/pamj.2021.38.27.26691
53. Hohlfeld AS, Kredo T, Davids E, Galloway M, Ndwandwe D, Oliver J, Pienaar E, Durao S. Specific strategies to increase access to Cochrane training opportunities in South Africa and the African region. Advances in Evidence Synthesis: special issue. Cochrane Database of Systematic Reviews 2020;(9 Suppl 1):291 https://doi.org/10.1002/14651858.CD202001
54. Local Burden of Disease Vaccine Coverage Collaborators (including Ndwandwe DE). Mapping routine measles vaccination in low- and middle-income countries. Nature 2020 Dec 16. doi: 10.1038/s41586-020-03043-4
55. Fegan G, Cheah PY, Data Sharing Working Group (including Ndwandwe D). Solutions to COVID-19 data sharing. Lancet Digital Health 2020 December 1; https://doi.org/10.1016/S2589-7500(20)30273-9
56. GBD 2019 Demographics Collaborators (including Ndwandwe DE). Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950-2019: a comprehensive demographic analysis for the Global Burden of Disease Study 2019. Lancet. 2020 Oct 17;396(10258):1160-1203. doi: 10.1016/S0140-6736(20)30977-6. PMID: 33069325
57. James SL, Castle CD, Dingels ZV, et al (including Ndwandwe DE). Estimating global injuries morbidity and mortality: methods and data used in the Global Burden of Disease 2017 study [published online ahead of print, 2020 Aug 24]. Inj Prev. 2020;injuryprev-2019-043531. doi:10.1136/injuryprev-2019-043531
58. Local Burden of Disease Diarrhoea Collaborators (Including Ndwandwe DE). Mapping geographical inequalities in oral rehydration therapy coverage in low-income and middle-income countries, 2000-17. Lancet Glob Health. 2020;8(8): e1038-e1060. doi:10.1016/S2214-109X(20)30230-8
59. Local Burden of Disease WaSH Collaborators (Including Ndwandwe DE). Mapping geographical inequalities in access to drinking water and sanitation facilities in low-income and middle-income countries, 2000-17. Lancet Glob Health. 2020;8(9):e1162-e1185. doi:10.1016/S2214-109X(20)30278-3
60. Nnaji CA, Iwu CJ, Ndwandwe DE, Jordan P, Wiysonge CS. Convalescent plasma or hyperimmune immunoglobulin for people with COVID-19. S Afr Med J. 2020 Jul 16;110(8):759-760.
61. Wiysonge CS, Mahasha P, Ndwandwe D, Ngcobo, Grimmer K, Dizon J, Burnett RJ, Cooper S. Contextualised strategies to increase childhood and adolescent vaccination coverage in South Africa: A mixed-methods study [protocol]. BMJ Open. 2020 Jun 4;10(6):e028476.
doi: 10.1136/bmjopen-2018-028476.
62. GBD 2019 Viewpoint Collaborators (including Ndwandwe DE). Five insights from the Global Burden of Disease Study 2019. Lancet. 2020 Oct 17;396(10258):1135-1159. doi: 10.1016/S0140-6736(20)31404-5. PMID: 33069324; PMCID: PMC7116361.
63. GBD Chronic Respiratory Disease Collaborators (including Ndwandwe DE). Prevalence and attributable health burden of chronic respiratory diseases, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 Lancet Respir Med 2020; 8: 585–96
64. Nnaji CA, Owoyemi AJ, Amaechi UA, Wiyeh AB, Ndwandwe DE, Wiysonge CS. Taking stock of global immunisation coverage progress: the gains, the losses and the journey ahead. Int Health. 2020 Jan 11. pii: ihz120. doi: 10.1093/inthealth/ihz120. [Epub ahead of print]. PMID: 31927563
65. James SL, Castle CD, Dingels ZV, et al (including Ndwandwe DE). Global injury morbidity and mortality from 1990 to 2017: results from the Global Burden of Disease Study 2017 [published online ahead of print, 2020 Apr 24]. Inj Prev. 2020;injuryprev-2019-043494. doi:10.1136/injuryprev-2019-043494
66. Reiner Jr RC, Hay SI, on behalf of the Local Burden of Disease Diarrhoea Collaborators (including Ndwandwe DE). Mapping geographical inequalities in childhood diarrhoeal morbidity and mortality in low-income and middle-income countries, 2000–17: analysis for the Global Burden of Disease Study 2017. Available online 6 May 2020. https://doi.org/10.1016/S0140-6736(20)30114-8
67. Local Burden of Disease Child Growth Failure Collaborators (including Ndwandwe DE). Mapping child growth failure across low- and middle-income countries. Nature. 2020;577(7789):231‐234. doi:10.1038/s41586-019-1878-8
68. LBD Double Burden of Malnutrition Collaborators (including Ndwandwe DE). Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017. Nat Med. 2020;26(5):750‐759. doi:10.1038/s41591-020-0807-6
69. Haagsma JA, James SL, Castle CD, Dingels ZV, Ndwandwe DE et al., Burden of injury along the development spectrum: associations between the Socio-demographic Index and disability-adjusted life year estimates from the Global Burden of Disease Study 2017. Inj Prev. 2020 Jan 8. pii: injuryprev-2019-043296. doi: 10.1136/injuryprev-2019-043296. [Epub ahead of print]
70. Local Burden of Disease Educational Attainment Collaborators (Including Ndwandwe DE). 2020. Mapping disparities in education across low- and middle-income countries. Nature. 2020 Jan;577(7789):235-238. doi: 10.1038/s41586-019-1872-1. Epub 2019 Dec 25. PMID: 31875853
71. Burstein R, Henry NJ, Collison ML, Marczak LB, Ndwandwe DE et al., 2019. Mapping 123 million neonatal, infant and child deaths between 2000 and 2017. Nature; volume 574, pages 353–358. doi: 10.1038/s41586-019-1545-0
72. Wiyeh AB, Cooper S, Jaca A, Mavundza E, Ndwandwe D, Wiysonge CS. 2019. Social media and HPV vaccination: Unsolicited public comments on a Facebook post by the Western Cape Department of Health provide insights into determinants of vaccine hesitancy in South Africa. Vaccine. 2019 Oct 8;37(43):6317-6323. doi: 10.1016/j.vaccine.2019.09.019. Epub 2019 Sep 11.
PMID: 31521412
73. GBD 2017 HIV collaborators (Including Ndwandwe D). Global, regional, and national incidence, prevalence, and mortality of HIV, 1980-2017, and forecasts to 2030, for 195 countries and territories: a systematic analysis for the Global Burden of Diseases, Injuries, and Risk Factors Study 2017. Lancet HIV. 2019 Aug 19. pii: S2352-3018(19)30196-1. doi: 10.1016/S2352-3018(19)30196-1 [Epub ahead of print], PMID: 31439534
74. Adetokunboh OO, Awotiwon A, Ndwandwe D, Uthman OA, Wiysonge CS. The burden of vaccine-preventable diseases among HIV-infected and HIV-exposed children in sub-Saharan Africa: a systematic review and meta-analysis. Hum Vaccin Immunother. 2019 May 22:1-16. doi: 10.1080/21645515.2019.1599676. [Epub ahead of print]. PMID: 30945963
75. Adamu AA, Uthman OA, Sambala EZ, Ndwandwe D, Wiyeh AB, Olukade T, Bishwajit G, Yaya S, Okwo-Bele JM, Wiysonge CS. Rural-Urban disparities in missed opportunities for vaccination in sub-Saharan Africa: A Multicountry Decomposition Analyses. Hum Vaccin Immunother. 2019 15(5):1191-1198. doi: 10.1080/21645515.2019.1575163. PMID: 30779684
76. Uthman OA, Sambala E, Adamu AA, Ndwandwe D, Wiyeh AB, Olukade T, Bishwajit G, Yaya S, Okwo-Bele JM, Wiysonge CS. 2018. Does it really matter where you live? A multilevel analysis of factors associated with missed opportunities for vaccination in sub-Saharan Africa. Hum Vaccin Immunother. 2018 14(10):2397-2404. doi: 10.1080/21645515.2018.1504524. PMID: 30059645
77. Sambala EZ, Uthman OA, Adamu A, Ndwandwe D, Wiyeh AB, Olukade T, Bishwajit G, Yaya S, Okwo-Bele JM, Wiysonge CS. 2018. Mind the Gap: What explains the education-related inequality in missed opportunities for vaccination in sub-Saharan Africa? Compositional and structural characteristics. Hum Vaccin Immunother. 2018 14(10):2365-2372. doi: 10.1080/21645515.2018.1460985. PMID: 29630441
78. Nyane NA, Tlaila TB, Malefane TG, Ndwandwe DE, Owira PMO. 2017. Metformin-like antidiabetic, cardio-protective and non-glycemic effects of naringenin: Molecular and pharmacological insights. Eur J Pharmacol. 2017 May 15;803: 103-111. doi: 10.1016/j.ejphar.2017.03.0428.
79. Baeten JM, Palanee-Phillips T, Brown ER, Schwartz K, Soto-Torres LE, Govender V, Mgodi NM, Matovu Kiweewa F, Nair G, Mhlanga F, Siva S, Bekker LG, Jeenarain N, Gaffoor Z, Martinson F, Makanani B, Pather A, Naidoo L, Husnik M, Richardson BA, Parikh UM, Mellors JW, Marzinke MA, Hendrix CW, van der Straten A, Ramjee G, Chirenje ZM, Nakabiito C, Taha TE, Jones J, Mayo A, Scheckter R, Berthiaume J, Livant E, Jacobson C, Ndase P, White
Peer-reviewed Publications
1st author publications
1. Ndwandwe DE, Runeyi S, Pienaar E, Mathebula L, Hohlfeld A, Wiysonge CS. Practices and trends in clinical trial registration in the Pan African Clinical Trials Registry (PACTR): a descriptive analysis of registration data. BMJ Open. 2022 Jan 25;12(1):e057474. doi: 10.1136/bmjopen-2021-057474. PMID: 35078852.
2. Ndwandwe D, Wiysonge CS. COVID-19 vaccines. Curr Opin Immunol. 2021 Jul 12;71:111-116. doi: 10.1016/j.coi.2021.07.003. Epub ahead of print. PMID: 34330017; PMCID: PMC8272971
3. Ndwandwe D, Mathebula L, Adetokunboh O, Kamadjeu R, Wiysonge CS. Cochrane corner: universal screening for SARS-CoV-2 infection. Pan African Medical Journal 2020 Dec 16;37:(Supp 1):48. [doi: 10.11604/pamj.supp.2020.37.1.26881]
4. Ndwandwe D, Ngcobo NJ, Adamu AA, Nnaji C, Mashunye T, Leufak AM, Cooper S, Uthman OA, Wiysonge CS. Country-Level Assessment of Missed Opportunities for Vaccination in South Africa: Protocol for Multilevel Analysis. JMIR Res Protoc. 2020 Sep 28;9(9):e16672.
doi: 10.2196/16672.
5. Ndwandwe D, Mathebula L, Kamadjeu R, Wiysonge CS. Cochrane corner: rapid point-of-care antigen and molecular-based tests for the diagnosis of COVID-19 infection. Supplement article - Research | Volume 37 (1): 10. 15 Sep 2020 | 10.11604/pamj.supp.2020.37.1.25982
6. Ndwandwe D, Nnaji CA, Mashunye T, Uthman OA, Wiysonge CS. Incomplete vaccination and associated factors among children aged 12–23 months in South Africa: an analysis of the South African demographic and health survey 2016. Human Vaccines & Immunotherapeutics 2020, July 23. Doi:10.1080/21645515.2020.1791509.
https://doi.org/10.1080/21645515.2020.1791509
7. Ndwandwe D, Dube K, Mathebula L, Wiysonge CS. 2019. Description of vaccine clinical trials in Africa: a narrative review. Hum Vaccin Immunother. 2020 Apr 2;16(4):972-980.
doi: 10.1080/21645515.2019.1693720. PMID: 31730397
8. Ndwandwe D, Uthman OA, Adamu A, Sambala E, Yusuf T, Bishwajit G, Yaya S, Wiysonge CS. Decomposing the gap in missed opportunities for vaccination between poor and non-poor in sub-Saharan Africa: A Multicountry Analyses. Hum Vaccin Immunother. 2018;14(10):2358-2364. doi: 10.1080/21645515.2018.1467685. PMID: 29688133
9. Ndwandwe DE, Abbai NS, Wand H, Ramjee G. The Need for Multi-product Technologies for Women Participating in Vaginal Microbicide Trials. AIDS research and human retroviruses. 2014: 30 (S1), A140-A141
10. Ndwandwe D, Nnaji CA, Wiysonge CS. The magnitude and determinants of missed opportunities for childhood vaccination in South Africa. Vaccines 2020, 8(4), 705; https://doi.org/10.3390/vaccines8040705
11. Ndwandwe, D., Runeyi, S., Mathebula, L. et al. Rotavirus vaccine clinical trials: a cross-sectional analysis of clinical trials registries. Trials 23, 945 (2022). https://doi.org/10.1186/s13063-022-06878-6
Senior authorship
12. Nnaji CA, Wiysonge CS, Cooper S, Mayeye A, Luphondo L, Mabuya T, Kalui N, Lesosky M, Ndwandwe D. Contextualising missed opportunities for children's vaccination: A theory-informed qualitative study in primary care settings in Cape Town, South Africa. Hum Vaccin Immunother. 2023 Jan 5:2162771. doi: 10.1080/21645515.2022.2162771. Epub ahead of print. PMID: 36601915.
13. Nnaji CA, Wiysonge CS, Adamu AA, Lesosky M, Mahomed H, Ndwandwe D. Missed Opportunities for Vaccination and Associated Factors among Children Attending Primary Health Care Facilities in Cape Town, South Africa: A Pre-Intervention Multilevel Analysis. Vaccines (Basel). 2022 May 16;10(5):785. doi: 10.3390/vaccines10050785. PMID: 35632542; PMCID: PMC9144782.
14. Mathebula, L., Runeyi, S., Wiysonge, C., Ndwandwe D. Clinical trial registration during COVID-19 and beyond in the African context: what have we learned?. Trials 23, 460 (2022). https://doi.org/10.1186/s13063-022-06412-8
15. Ngandu, N.K., Mmotsa, T.M., Dassaye, R. Thabetha A, Odendaal, Langdown N, Ndwandwe D. Hospital acquired COVID-19 infections amongst patients before the rollout of COVID-19 vaccinations, a scoping review. BMC Infect Dis 22, 140 (2022). https://doi.org/10.1186/s12879-022-07128-5
16. Jaca A, Sishuba M, Jacobson Vann JC, Wiysonge CS, Ndwandwe D. Interventions to improve vaccination uptake among adults. Cochrane Database of Systematic Reviews 2021, Issue 11. Art. No.: CD015057. DOI: 10.1002/14651858.CD015057. Accessed 17 November 2021.
17. Adetokunboh O, Iwu-Jaja CJ, Nnaji CA, Ndwandwe D. Missed opportunities for vaccination in Africa. Curr Opin Immunol. 2021 Aug; 71:55-61. doi: 10.1016/j.coi.2021.05.002. Epub 2021 Jun 1. PMID: 34087523.
18. Nnaji CA, Wiysonge CS, Lesosky M, Mahomed H, Ndwandwe D. COVID-19 and the Gaping Wounds of South Africa’s Suboptimal Immunisation Coverage: An Implementation Research Imperative for Assessing and Addressing Missed Opportunities for Vaccination. Vaccines. 2021; 9(7):691. https://doi.org/10.3390/vaccines9070691
19. Leufak AM, Ndwandwe D. Applying innovative strategies to achieve Universal Health Coverage in the African Region. (Position paper). SEEJPH 2021, posted: 18 May 2021. DOI: 10.11576/seejph-4447
Co-authored publications
20. Mthembu SXH, Mazibuko-Mbeje SE, Moetlediwa MT, Muvhulawa N, Silvestri S, Orlando P, Nkambule BB, Muller CJF, Ndwandwe D, Basson AK, Tiano L, Dludla PV. Sulforaphane: A nutraceutical against diabetes-related complications. Pharmacol Res. 2023 Sep 12;196:106918. doi: 10.1016/j.phrs.2023.106918. Epub ahead of print. PMID: 37703962.
21. Dludla PV, Cirilli I, Marcheggiani F, Silvestri S, Orlando P, Muvhulawa N, Moetlediwa MT, Nkambule BB, Mazibuko-Mbeje SE, Hlengwa N, et al (including Ndwandwe D). Potential Benefits of Coffee Consumption on Improving Biomarkers of Oxidative Stress and Inflammation in Healthy Individuals and Those at Increased Risk of Cardiovascular Disease. Molecules. 2023; 28(18):6440. https://doi.org/10.3390/molecules28186440
22. Dludla PV, Cirilli I, Marcheggiani F, Silvestri S, Orlando P, Muvhulawa N, Moetlediwa MT, Nkambule BB, Mazibuko-Mbeje SE, Hlengwa N, et al (including Ndwandwe D). Bioactive Properties, Bioavailability Profiles, and Clinical Evidence of the Potential Benefits of Black Pepper (Piper nigrum) and Red Pepper (Capsicum annum) against Diverse Metabolic Complications. Molecules. 2023; 28(18):6569. https://doi.org/10.3390/molecules28186569
23. Wiysonge CS, Ndwandwe D and Mathebula L. Measles and whooping cough outbreaks in South Africa: a sign of low vaccination coverage, experts warn. The conversation article published June 15, 2023. URL: https://theconversation.com/measles-and-whooping-cough-outbreaks-in-south-africa-a-sign-of-low-vaccination-coverage-experts-warn-205515
Masuku, S., Mooa, R. S., Peu, M. D., Ndwandwe, D., Moloto, T. B. S., & van der Walt, M. (2023). Exploring the role of healthcare personnel in designing Tuberculosis Infection Prevention and Control measures in healthcare settings: A scoping review.
24. Foster I, Amuasi J, Geelen J, Miyagawa S, Böcking D, Hagen H, Sigfrid L, Norton A; GloPID-R Clinical Trial Networks and Funders Working Group (including Ndwandwe D). How funders can support improved clinical trial practice for outbreaks. Lancet. 2023 Jul 1;402(10395):26. doi: 10.1016/S0140-6736(23)01226-6. PMID: 37393101.
25. Shelly CE, Logan C, Skorochod B, Wiyeh A, Ndwandwe D, Choko A, Valea I, Titanji BK. Creating a best practice template for participant communication plans in global health clinical studies. Trials. 2023 Mar 2;24(1):158. doi: 10.1186/s13063-023-07185-4. PMID: 36864516; PMCID: PMC9983505.
26. Ibrahim SK, Ndwandwe DE, Thomas K, Sigfrid L, Norton A. Sudan virus disease outbreak in Uganda: urgent research gaps. BMJ Glob Health. 2022 Dec;7(12):e010982. doi: 10.1136/bmjgh-2022-010982. PMID: 36585031; PMCID: PMC9809242.
27. Shelly CE, Logan C, Skorochod B, Wiyeh A, Ndwandwe D, Choko A, Valea I, Titanji BK. Creating a Best Practice Template for Participant Communication Plans in Global Health Clinical Studies. Research Square; 2022. DOI: 10.21203/rs.3.rs-2378482/v1.
28. GBD 2019 Diabetes and Air Pollution Collaborators (including Ndwandwe D). Estimates, trends, and drivers of the global burden of type 2 diabetes attributable to PM2·5 air pollution, 1990-2019: an analysis of data from the Global Burden of Disease Study 2019. Lancet Planet Health. 2022 Jul;6(7):e586-e600. doi: 10.1016/S2542-5196(22)00122-X. PMID: 35809588.
29. GBD 2019 Human Resources for Health Collaborators (including Ndwandwe D). Measuring the availability of human resources for health and its relationship to universal health coverage for 204 countries and territories from 1990 to 2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet. 2022 Jun 4;399(10341):2129-2154. doi: 10.1016/S0140-6736(22)00532-3. Epub 2022 May 23. PMID: 35617980; PMCID: PMC9168805.
30. Be ZO and Ndwandwe D. AFRICA IS SEEKING COVID TREATMENTS BUT MAJOR HURDLES BLOCK THE WAY. Nature. 2021 Nov 4;599:25.
31. Mathebula L, Mapahla L, Nurkhametova D, Ziganshina LE, Mazinu M, Jordan E, Ndwandwe DE, Kredo T. Planned, ongoing and completed tuberculosis treatment trials in Brazil, Russia, India, China, and South Africa: a 2019 cross-sectional descriptive analysis. BMJ Open. 2022;12:e057941. doi:10.1136/bmjopen-2021-057941
32. Wiysonge, C. S., Ndwandwe, D., Mathebula, L., Goga, A., & Gray, G. (2022). Randomised trials of COVID-19 vaccines in Africa – charting the path forward. South African Journal of Science, 118(5/6). https://doi.org/10.17159/sajs.2022/13224
33. Mouako AL, Zunza M, Ndwandwe D, Uthman OA, Wiysonge CS. Health research publications by South African authors from 1996 to 2015: a bibliometric analysis. Pan Afr Med J. 2022 May 12;42:31. doi: 10.11604/pamj.2022.42.31.28968. PMID: 35910065; PMCID: PMC9288119.
34. Mavundza EJ, Ndwandwe D, Wiysonge CS. COVID-19 vaccine demand protest might have increased vaccine acceptance and uptake in South Africa. Hum Vaccin Immunother. 2022 Apr 18:1-3. doi: 10.1080/21645515.2022.2064691. Epub ahead of print. PMID: 35435798.
35. Merson L, Ndwandwe D, Malinga T, Paparella G, Oneil K, Karam G, Terry RF. Promotion of data sharing needs more than an emergency: An analysis of trends across clinical trials registered on the International Clinical Trials Registry Platform. Wellcome Open Res 21 Mar 2022, 7:101. doi: https://doi.org/10.12688/wellcomeopenres.17700.1
36. Uthman OA, Ndwandwe D, Uthman MMB, Yaya S, Wiysonge CS. Multilevel Analysis of Individual and Contextual Factors Associated with Polio Non-Vaccination in Africa: Further Analyses to Enhance Policy and Opportunity to Save More Lives. Vaccines 2021; 9(7):683. https://doi.org/10.3390/vaccines9070683
37. Nnaji CA, Ndwandwe D, Lesosky M, Mahomed H, Wiysonge CS. Tackling missed opportunities for vaccination in a new era of immunisation. Lancet. 2021 Jun 2:S0140-6736(21)01226-5. Epub ahead of print. PMID: 34089659; PMCID: PMC8172164. doi: 10.1016/S0140-6736(21)01226-5
38. Wiysonge CS, Ndwandwe D, Ryan J, Jaca A, Batouré O, Anya BM, Cooper S. 2021. Vaccine hesitancy in the era of COVID-19: could lessons from the past help in divining the future? Hum Vaccin Immunother. 2021 Mar 8;1-3. doi: 10.1080/21645515.2021.1893062.
39. Mashunye TR, Ndwandwe DE, Dube KR, Shey M, Shelton M, Wiysonge CS. Fractional dose compared with standard dose inactivated poliovirus vaccine in children: a systematic review and meta-analysis. Lancet Infect Dis. 2021 Apr 30:S1473-3099(20)30693-9. doi: 10.1016/S1473-3099(20)30693-9. Online ahead of print. PMID: 33939958
40. Mathebula L, Ndwandwe DE, Pienaar E, Wiysonge CS. Effects of vaccines in protecting against Ebola virus disease: protocol for a systematic review. BMJ Open. 2019 Jul 3;9(7):e029617. doi: 10.1136/bmjopen-2019-029617.PMID: 31272985
41. Mahasha P, Ndwandwe D, Mavundza E, Shey M, Wiysonge CS. Systematic review protocol on Bacillus Calmette-Guerin (BCG) revaccination and protection against tuberculosis BMJ Open 2019;9:e027033. doi: 10.1136/bmjopen-2018-027033.
42. Mashunye TR, Ndwandwe D, Dube K, Shey M, Wiysonge CS. A protocol for a systematic review and meta-analysis of fractional dose compared to standard dose inactivated polio vaccination in children. BMJ Open. 2019 Mar 9;9(3):e023308. doi: 10.1136/bmjopen-2018-023308. PMID: 30852530
43. Sambala EZ, Ndwandwe DE, Imaan LM, Wiysonge CS. Evaluation of influenza surveillance systems in sub-Saharan Africa: a systematic review protocol. BMJ Open. 2019 Jan 28;9(1): e023335. doi: 10.1136/bmjopen-2018-023335.PMID: 30782704
44. Adetokunboh OO, Ndwandwe D, Awotiwon A, Uthman OA, Wiysonge CS. Vaccination among HIV-infected, HIV-exposed uninfected and HIV-uninfected children: a systematic review and meta-analysis of evidence related to vaccine efficacy and effectiveness. Hum Vaccin Immunother. 2019 May 22:1-12. doi: 10.1080/21645515.2019.1599677. [Epub ahead of print]. PMID: 30945967
45. Nzuza S, Ndwandwe DE, Owira PMO. Naringin protects against HIV-1 protease inhibitors-induced pancreatic β-cell dysfunction and apoptosis. Mol Cell Endocrinol. 2016 Dec 5; 437:1-10. doi: 10.1016/j.mce.2016.07.041. PMID: 27496642
46. Warner DF, Ndwandwe DE, Abrahams GL, Kana BD, Machowski, E, Venclovas, C. and Mizrahi V. 2010. Essential roles for imuA′- and imuB-encoded accessory factors in DnaE2-dependent mutagenesis in Mycobacterium tuberculosis. PNAS. 107 (29): 13093-13098
47. Achoki T, Sartorius B, Watkins D, Glenn SD, Kengne AP, Oni T, Wiysonge CS, Walker A, Adetokunboh OO, Babalola TK, Bolarinwa OA, Claassens MM, Cowden RG, Day CT, Ezekannagha O, Ginindza TG, Iwu CCD, Iwu CJ, Karangwa I, Katoto PD, Kugbey N, Kuupiel D, Mahasha PW, Mashamba-Thompson TP, Mensah GA, Ndwandwe DE, Nnaji CA, Ntsekhe M, Nyirenda TE, Odhiambo JN, Oppong Asante K, Parry CDH, Pillay JD, Schutte AE, Seedat S, Sliwa K, Stein DJ, Tanser FC, Useh U, Zar HJ, Zühlke LJ, Mayosi BM, Hay SI, Murray CJL, Naghavi M. Health trends, inequalities and opportunities in South Africa's provinces, 1990-2019: findings from the Global Burden of Disease 2019 Study. J Epidemiol Community Health. 2022 Jan 19:jech-2021-217480. doi: 10.1136/jech-2021-217480. Epub ahead of print. PMID: 35046100.
48. Bergman H, Henschke N, Hungerford D, Pitan F, Ndwandwe D, Cunliffe N, Soares-Weiser K. Vaccines for preventing rotavirus diarrhoea: vaccines in use. Cochrane Database of Systematic Reviews 2021, Issue 11. Art. No.: CD008521. DOI: 10.1002/14651858.CD008521.pub6. Accessed 17 November 2021.
49. Bhattacharjee NV, Schaeffer LE, Hay SI; Local Burden of Disease Exclusive Breastfeeding Collaborators (including Ndwandwe D). Mapping inequalities in exclusive breastfeeding in low- and middle-income countries, 2000-2018. Nat Hum Behav. 2021 Jun 3. doi: 10.1038/s41562-021-01108-6. Epub ahead of print. PMID: 34083753.
50. Adetokunboh O, Iwu-Jaja CJ, Nnaji CA, and Ndwandwe D. Missed opportunities for vaccination in Africa. Current Opinion in Immunology 2021, 71:55–61. Doi: https://doi.org/10.1016/j.coi.2021.05.002.
51. Hohlfeld ASJ, Mathebula L, Pienaar ED, Abrams A, Lutje V, Ndwandwe D, Kredo T.
Tuberculosis treatment intervention trials in Africa: A cross-sectional bibliographic study and spatial analysis. PLoS One. 2021 Mar 19;16(3):e0248621. doi: 10.1371/journal.pone.0248621. eCollection 2021.PMID: 33739989
52. Malinga T, Wiysonge CS, Ndwandwe D, Okeibunor JC, Talisuna AO. 2021. A scoping review of the impact of long-distance truck drivers on the spread of COVID-19 infection. PAMJ. Volume 38, Article 27, 12 Jan 2021 | 10.11604/pamj.2021.38.27.26691
53. Hohlfeld AS, Kredo T, Davids E, Galloway M, Ndwandwe D, Oliver J, Pienaar E, Durao S. Specific strategies to increase access to Cochrane training opportunities in South Africa and the African region. Advances in Evidence Synthesis: special issue. Cochrane Database of Systematic Reviews 2020;(9 Suppl 1):291 https://doi.org/10.1002/14651858.CD202001
54. Local Burden of Disease Vaccine Coverage Collaborators (including Ndwandwe DE). Mapping routine measles vaccination in low- and middle-income countries. Nature 2020 Dec 16. doi: 10.1038/s41586-020-03043-4
55. Fegan G, Cheah PY, Data Sharing Working Group (including Ndwandwe D). Solutions to COVID-19 data sharing. Lancet Digital Health 2020 December 1; https://doi.org/10.1016/S2589-7500(20)30273-9
56. GBD 2019 Demographics Collaborators (including Ndwandwe DE). Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950-2019: a comprehensive demographic analysis for the Global Burden of Disease Study 2019. Lancet. 2020 Oct 17;396(10258):1160-1203. doi: 10.1016/S0140-6736(20)30977-6. PMID: 33069325
57. James SL, Castle CD, Dingels ZV, et al (including Ndwandwe DE). Estimating global injuries morbidity and mortality: methods and data used in the Global Burden of Disease 2017 study [published online ahead of print, 2020 Aug 24]. Inj Prev. 2020;injuryprev-2019-043531. doi:10.1136/injuryprev-2019-043531
58. Local Burden of Disease Diarrhoea Collaborators (Including Ndwandwe DE). Mapping geographical inequalities in oral rehydration therapy coverage in low-income and middle-income countries, 2000-17. Lancet Glob Health. 2020;8(8): e1038-e1060. doi:10.1016/S2214-109X(20)30230-8
59. Local Burden of Disease WaSH Collaborators (Including Ndwandwe DE). Mapping geographical inequalities in access to drinking water and sanitation facilities in low-income and middle-income countries, 2000-17. Lancet Glob Health. 2020;8(9):e1162-e1185. doi:10.1016/S2214-109X(20)30278-3
60. Nnaji CA, Iwu CJ, Ndwandwe DE, Jordan P, Wiysonge CS. Convalescent plasma or hyperimmune immunoglobulin for people with COVID-19. S Afr Med J. 2020 Jul 16;110(8):759-760.
61. Wiysonge CS, Mahasha P, Ndwandwe D, Ngcobo, Grimmer K, Dizon J, Burnett RJ, Cooper S. Contextualised strategies to increase childhood and adolescent vaccination coverage in South Africa: A mixed-methods study [protocol]. BMJ Open. 2020 Jun 4;10(6):e028476.
doi: 10.1136/bmjopen-2018-028476.
62. GBD 2019 Viewpoint Collaborators (including Ndwandwe DE). Five insights from the Global Burden of Disease Study 2019. Lancet. 2020 Oct 17;396(10258):1135-1159. doi: 10.1016/S0140-6736(20)31404-5. PMID: 33069324; PMCID: PMC7116361.
63. GBD Chronic Respiratory Disease Collaborators (including Ndwandwe DE). Prevalence and attributable health burden of chronic respiratory diseases, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 Lancet Respir Med 2020; 8: 585–96
64. Nnaji CA, Owoyemi AJ, Amaechi UA, Wiyeh AB, Ndwandwe DE, Wiysonge CS. Taking stock of global immunisation coverage progress: the gains, the losses and the journey ahead. Int Health. 2020 Jan 11. pii: ihz120. doi: 10.1093/inthealth/ihz120. [Epub ahead of print]. PMID: 31927563
65. James SL, Castle CD, Dingels ZV, et al (including Ndwandwe DE). Global injury morbidity and mortality from 1990 to 2017: results from the Global Burden of Disease Study 2017 [published online ahead of print, 2020 Apr 24]. Inj Prev. 2020;injuryprev-2019-043494. doi:10.1136/injuryprev-2019-043494
66. Reiner Jr RC, Hay SI, on behalf of the Local Burden of Disease Diarrhoea Collaborators (including Ndwandwe DE). Mapping geographical inequalities in childhood diarrhoeal morbidity and mortality in low-income and middle-income countries, 2000–17: analysis for the Global Burden of Disease Study 2017. Available online 6 May 2020. https://doi.org/10.1016/S0140-6736(20)30114-8
67. Local Burden of Disease Child Growth Failure Collaborators (including Ndwandwe DE). Mapping child growth failure across low- and middle-income countries. Nature. 2020;577(7789):231‐234. doi:10.1038/s41586-019-1878-8
68. LBD Double Burden of Malnutrition Collaborators (including Ndwandwe DE). Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017. Nat Med. 2020;26(5):750‐759. doi:10.1038/s41591-020-0807-6
69. Haagsma JA, James SL, Castle CD, Dingels ZV, Ndwandwe DE et al., Burden of injury along the development spectrum: associations between the Socio-demographic Index and disability-adjusted life year estimates from the Global Burden of Disease Study 2017. Inj Prev. 2020 Jan 8. pii: injuryprev-2019-043296. doi: 10.1136/injuryprev-2019-043296. [Epub ahead of print]
70. Local Burden of Disease Educational Attainment Collaborators (Including Ndwandwe DE). 2020. Mapping disparities in education across low- and middle-income countries. Nature. 2020 Jan;577(7789):235-238. doi: 10.1038/s41586-019-1872-1. Epub 2019 Dec 25. PMID: 31875853
71. Burstein R, Henry NJ, Collison ML, Marczak LB, Ndwandwe DE et al., 2019. Mapping 123 million neonatal, infant and child deaths between 2000 and 2017. Nature; volume 574, pages 353–358. doi: 10.1038/s41586-019-1545-0
72. Wiyeh AB, Cooper S, Jaca A, Mavundza E, Ndwandwe D, Wiysonge CS. 2019. Social media and HPV vaccination: Unsolicited public comments on a Facebook post by the Western Cape Department of Health provide insights into determinants of vaccine hesitancy in South Africa. Vaccine. 2019 Oct 8;37(43):6317-6323. doi: 10.1016/j.vaccine.2019.09.019. Epub 2019 Sep 11.
PMID: 31521412
73. GBD 2017 HIV collaborators (Including Ndwandwe D). Global, regional, and national incidence, prevalence, and mortality of HIV, 1980-2017, and forecasts to 2030, for 195 countries and territories: a systematic analysis for the Global Burden of Diseases, Injuries, and Risk Factors Study 2017. Lancet HIV. 2019 Aug 19. pii: S2352-3018(19)30196-1. doi: 10.1016/S2352-3018(19)30196-1 [Epub ahead of print], PMID: 31439534
74. Adetokunboh OO, Awotiwon A, Ndwandwe D, Uthman OA, Wiysonge CS. The burden of vaccine-preventable diseases among HIV-infected and HIV-exposed children in sub-Saharan Africa: a systematic review and meta-analysis. Hum Vaccin Immunother. 2019 May 22:1-16. doi: 10.1080/21645515.2019.1599676. [Epub ahead of print]. PMID: 30945963
75. Adamu AA, Uthman OA, Sambala EZ, Ndwandwe D, Wiyeh AB, Olukade T, Bishwajit G, Yaya S, Okwo-Bele JM, Wiysonge CS. Rural-Urban disparities in missed opportunities for vaccination in sub-Saharan Africa: A Multicountry Decomposition Analyses. Hum Vaccin Immunother. 2019 15(5):1191-1198. doi: 10.1080/21645515.2019.1575163. PMID: 30779684
76. Uthman OA, Sambala E, Adamu AA, Ndwandwe D, Wiyeh AB, Olukade T, Bishwajit G, Yaya S, Okwo-Bele JM, Wiysonge CS. 2018. Does it really matter where you live? A multilevel analysis of factors associated with missed opportunities for vaccination in sub-Saharan Africa. Hum Vaccin Immunother. 2018 14(10):2397-2404. doi: 10.1080/21645515.2018.1504524. PMID: 30059645
77. Sambala EZ, Uthman OA, Adamu A, Ndwandwe D, Wiyeh AB, Olukade T, Bishwajit G, Yaya S, Okwo-Bele JM, Wiysonge CS. 2018. Mind the Gap: What explains the education-related inequality in missed opportunities for vaccination in sub-Saharan Africa? Compositional and structural characteristics. Hum Vaccin Immunother. 2018 14(10):2365-2372. doi: 10.1080/21645515.2018.1460985. PMID: 29630441
78. Nyane NA, Tlaila TB, Malefane TG, Ndwandwe DE, Owira PMO. 2017. Metformin-like antidiabetic, cardio-protective and non-glycemic effects of naringenin: Molecular and pharmacological insights. Eur J Pharmacol. 2017 May 15;803: 103-111. doi: 10.1016/j.ejphar.2017.03.0428.
79. Baeten JM, Palanee-Phillips T, Brown ER, Schwartz K, Soto-Torres LE, Govender V, Mgodi NM, Matovu Kiweewa F, Nair G, Mhlanga F, Siva S, Bekker LG, Jeenarain N, Gaffoor Z, Martinson F, Makanani B, Pather A, Naidoo L, Husnik M, Richardson BA, Parikh UM, Mellors JW, Marzinke MA, Hendrix CW, van der Straten A, Ramjee G, Chirenje ZM, Nakabiito C, Taha TE, Jones J, Mayo A, Scheckter R, Berthiaume J, Livant E, Jacobson C, Ndase P, White R, Patterson K, Germuga D, Galaska B, Bunge K, Singh D, Szydlo DW, Montgomery ET, Mensch BS, Torjesen K, Grossman CI, Chakhtoura N, Nel A, Rosenberg Z, McGowan I, Hillier S; MTN-020–ASPIRE Study Team (including Ndwandwe, D). 2016. Use of a Vaginal Ring Containing Dapivirine for HIV-1 Prevention in Women. N Engl J Med. 2016 Dec 1;375(22):2121-2132.
80. Jagesur L, Maharaj R, Haridutt A, Abbai N, Ndwandwe D, Ramjee G. Introduction of a Novel Monitoring Tool to Reduce Specimen Archive Errors. AIDS research and human retroviruses 2014: 30 (S1), A222-A222
- 81. Mizrahi V, Warner D, Ndwandwe DE, Abrahams G and Venclovas C. 2012. A novel inducible mutagenesis system in Mycobactm tuberculosis. The FASEB Journal. vol. 26 no. 1 Supplement 222.1 R, Patterson K, Germuga D, Galaska B, Bunge K, Singh D, Szydlo DW, Montgomery ET, Mensch BS, Torjesen K, Grossman CI, Chakhtoura N, Nel A, Rosenberg Z, McGowan I, Hillier S; MTN-020–ASPIRE Study Team (including Ndwandwe, D). 2016. Use of a Vaginal Ring Containing Dapivirine for HIV-1 Prevention in Women. N Engl J Med. 2016 Dec 1;375(22):2121-2132.
80. Jagesur L, Maharaj R, Haridutt A, Abbai N, Ndwandwe D, Ramjee G. Introduction of a Novel Monitoring Tool to Reduce Specimen Archive Errors. AIDS research and human retroviruses 2014: 30 (S1), A222-A222
81. Mizrahi V, Warner D, Ndwandwe DE, Abrahams G and Venclovas C. 2012. A novel inducible mutagenesis system in Mycobacterium tuberculosis. The FASEB Journal. vol. 26 no. 1 Supplement 222.1
Additional Information
- Grants and Fellowship , South African National Clinical Trial Register Role: Principal Investigator Award: R 600 000 Year: 2022 Funder: South African Medical Research Council Pan African Clinical Trial Register (PACTR)” Role: Principal investigator Award: R83 100 Funder: SAMRC baseline budget Year: 2021 South African National Clinical Trial Register Role: Principal Investigator Award: R 3 395 931 Funder: National Department of Health Year: 2020-2022 Name: Towards harmonization of data sharing information requirements in ICTRP registries project, part of the COVID-19 Research Coalition data sharing group. Role: Co-Principal Investigator Award: R113 565.14 Year: 2021 Name: Country-level assessment of the missed opportunity for vaccination in South Africa: Thuthuka funding instrument (NRF rating track). Role: Principal Investigator Award: R568 000 Funder: National Research Foundation Year: 2019-2021 Name: Knowledge Interchange and Collaboration Role: Principal Investigator Award: R20 000 Funder: National Research Foundation Year: 2018 KwaZulu Natal Research Institute for TB and HIV travel award (KRITH) to travel to the US, (Harvard University, School of public health) to learn Mass Spectroscopy Technique Role: Principal Investigator Award: Funder: KwaZulu Natal Research Institute for TB and HIV travel award (KRITH) Year: 2011 Columbia University - Southern African Fogarty AIDS Training and Research Programme (AITRP) fellowship for pre-doctoral training to travel to the US (Harvard University, School of public health) to learn Pull-down assay and Mass Spectroscopy Techniques Role: Principal Investigator Award: R57 772.30 Funder: Columbia University - Southern African Fogarty AIDS Training and Research Programme (AITRP) fellowship Year: 2010 Mellon Postgraduate Mentoring Scheme, University of the Witwatersrand Role: co-Principal Investigator Award: R450 000 Funder: Mellon Postgraduate Mentoring Scheme, University of the Witwatersrand Year: 2009-2011 DoL Scarce Skills Doctoral Scholarship, National Research Foundation Role: Principal Investigator Award: R360, 000 Funder: National Research Foundation Year: 2008-2010 Awarded a travelling fellowship from the Cape Biotechnology Trust to attend the CSIR Advanced Design & Development of potential Drugs Against TB Workshop held in Pretoria on 3-4 August 2009 Role: Principal Investigator Award: R5000 Funder: Cape Biotechnology Trust Year: 2009 South African TB/AIDS Research Training (SATBAT) grant from Perinatal HIV Research Unit (PHRU) Role: co-Principal Investigator Award: R5000 Funder: Perinatal HIV Research Unit (PHRU) Year: 2009 Scientometric summary as of 17 February 2023: Google Scholar https://scholar.google.co.za/citations?user=6sT5FAQAAAAJ&hl=en&oi=ao Citations 4982 h-index 25 i10-index 35 Peer-reviewed Publications 1st author publications Ndwandwe DE, Runeyi S, Pienaar E, Mathebula L, Hohlfeld A, Wiysonge CS. Practices and trends in clinical trial registration in the Pan African Clinical Trials Registry (PACTR): a descriptive analysis of registration data. BMJ Open. 2022 Jan 25;12(1):e057474. doi: 10.1136/bmjopen-2021-057474. PMID
Affiliations
- Nominated to be co-chair of the 2023 Cochrane Colloquium Abstract committee
- Co-chair of the Poster session 1 at the Cochrane SA virtual National Symposium 2022. 22 November 2022
- Peer reviewer, Chan Soon-Shiong Family Foundation (CSSFF) and the South African Medical Research Council (SAMRC) Student and Scholarship programme. November 2022
- Member, Pandemic PACT advisory group. November 2022.
- Secretariat of National Advisory Group on Immunisation (NAGI) Working Group on Vaccine Hesitancy, March 2019-2021
- Chair and non-executive director of EH WOZA! Board, March 2020-
- Member, Scholarship Selection Committee (RCD, SAMRC). May 2020-
- Member, Cochrane Developing Countries Stipend Committee. February 2018 –
- Member, Global Research Collaboration for Infectious Disease Preparedness and Response (GloPID-R) Liaison Committee. Oct 2021
- Member, Global Research Collaboration for Infectious Disease Preparedness and Response (GloPID-R) Clinical Trials Working Group. Nov 2021-
- COVID-19 Research Coalition Data sharing Working Group. Mar 2020-
- Member, International Clinical Trial Registry Network (ICTRP). October 2017-Ongoing
- Member, Clinical Research Initiative for Global Health (CRIGH). November 2019-Ongoing
Timeline
Advanced Diploma - Vaccinology
University of Geneva
05.2022 - 06.2022
Master of Science - Vaccinology
University of Lausanne
09.2021 - 09.2021
Deputy Director
Cochrane South Africa, South African Medical Research Council
05.2021 - Current
Board Chair
Eh!Woza
01.2020 - Current
Specialist Scientist
Cochrane, South African Medical Research Council
10.2017 - Current
Senior Researcher, Project Lead
Wits Reproductive Health & HIV Institute
02.2016 - 07.2017
Postdoctoral Research Fellow
School, Health Sciences, University of KwaZulu-Natal
01.2015 - 01.2016
Senior Scientist
South African Medical Research Council
01.2013 - 01.2015
Teaching Assistant
University of the Witwatersrand
01.2007
Limpopo, Microbiology Department
01.2006
PhD - Molecular Mycobacteriology
University of the Witwatersrand
MSc - Microbial Genetics
University of the Witwatersrand
Bachelor of Science (Honours) - Microbiology
University of Limpopo
Bachelor of Science - Physiology and Microbiology
University of Limpopo
Matric Senior Certificate - undefined
Sikhulile Secondary School
Master’s - public health
University of Cape Town
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